Under the vision of Viksit Bharat 2047, the Office of the Principal Scientific Adviser to the Government of India has been driving forward a range of initiatives and missions - from IndiaAI and National One Health Mission to RuTAG, सह Sankalp, RSVC, S&T Cluster and Manthan. The last two years have marked significant progress: broader access to scholarly infrastructure through I-STEM, open knowledge for researchers and academicians through One Nation One Subscription, and dedicated funding pathways via Anusandhan National Research Foundation (ANRF) and Research Development and Innovation fund. Missions like the National Green Hydrogen Mission and National Quantum Mission reflect the urgency of the moment, and India is rising to meet it on a global scale. Dr (Mrs.) Parvinder Maini