Several cities have seen major investments in research infrastructure and in creating pools of trained scientific manpower, while establishing high-end S&T institutions. Similarly, knowledge industry has also grown as an enterprise in these cities. Yet, connect between R&D institutions, academia-including state universities, and industry remains as a challenge. The aim of creating city research clusters is to provide a platform to leverage the complementary strengths through effective collaboration and cooperation by developing a functional connect. The clusters will serve as hubs, which will interact with the broader city ecosystem including state universities, colleges, medical schools and local administration. The effort will also address development of research programmes in the state university system by providing an enabling ecosystem.